Description

Curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) are extracted as Curcumin C3 Complex from turmeric root (Curcuma longa) with a unique composition. Curcuminoids have been scientifically proven to be powerful antioxidants preventing the formation of free radicals and neutralizing already-formed free radicals, i.e., higher ORAC (Oxygen Radical Absorbance Capacity) value than green tea extract, green coffee extract and grape seed extract. Curcuminoids are therefore considered to be a “bio-protectant” due to its dual activity of prevention and intervention of free radicals. Curcuminoids may also relieve temporary joint inflammation and pain that occur after overexertion during intensive physical activity. From mode of action point of view, Arachidonic Acid is broken down via two major pathways (Arachidonic Acid Cascades). AA cascade via Cyclooxygenase, or COX pathway, generates inflammation-causing Prostaglandins and Thromboxanes, and AA cascade via Lipoxygenase or LOX pathway, generates inflammation-causing Leukotrienes. Cyclooxygenase 2 (COX-2) becomes abundant in activated/stimulated macrophages and other cells at sites of inflammation.Curcuminoids naturally inhibit COX and LOX enzymes.

BioPerine^® is a patented natural extract from black pepper fruit which improves the absorption and bioavailability of nutrients. The non-specific mechanisms for improving rapid absorption of nutrients may include increased blood supply to the GI tract, increased active nutrient transport by modulating efflux mechanisms (P-glycoprotein inhibition) and inhibition of solubilization by modulating metabolizing enzymes (glucuronidation).